The crosslinking theory of aging has been gaining acceptance at a plastered pace, as evidenced by many independent rediscoveries. while several earlier studies were indicative, none seemed conclusive until it was shown, using differential gear Scanning Calorimetry (DSC), that protein from young human nouss could be made to most resemble protein from old brains by exposing it to either of two alone different crosslinking agents (glutaraldehyde and dipotassium diperoxy sulfate). This work has forthwith been repeated with additional brain material, and a statistically more significant number of determinations. It is now shown that a treatment of brain protein with either one or two chemically totally different compounds which have no property in common except that both be crosslinkers, changes young brain protein so that it greatly resembles old, crosslinked protein. This shows that crosslinking reactions are affect in the age related changes in the studied proteins.
developmental aging and cross-linking were first proposed in 1942 by Johan Bjorksten. He apply this theory to aging diseases such as sclerosis, a declining tolerant system and the most obvious example of cross-linking, loss of breeze in the spit out.
Collagen is one of the most common proteins found in the skin, tendons, ligaments, bone and cartilage. Collagen protein can be compared to the legs of a ladder with precise some rungs. Each protein is connected to its neighbors by other rungs forming a cross-link. In young people there are few cross-links and the ladders are free to move up and down. The collagen stays flossy and pliable. With age however the number of cross-links increases, causing the skin to creep and become less soft and pliable. It is thought that these cross-links increases, causing the skin to shrink and become less soft and pliable. It is thought that these cross-links obtain to obstruct the passage of nutrients and waste between cells.
Cross-linking also appears to turn over when older...If you want to get a full essay, order it on our website: Orderessay
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